TLR4 and hypertensive disorder: Eissler et al. showed that hypertension is accompanied by upregulated TLR4 expression and activity[27].TLR4 knockout mice develop less-severe left ventricular hypertrophy following aortic banding compared to respective sham controls [28].In the study, we found that cardiac and renal expression of TLR4isincreased by Aldo infusion, which results in an activation of inflammatory response.