After 2 h of infection, mean absorbance significantly increased (p<0.05) from 0.066 ± 0.01 and 0.07 ± 0.02 in uninfected controls to 0.18 ± 0.04 in infected cells, indicating that C. parvum infected cells have an increased level of activated proteins that bind to the SH2 domain of SHP-2. The gene discussed is PTPN11; the disease is infection.