INS and type 2 diabetes mellitus: In particular, both a primary and a secondary insulin response are evident and the variation of the shape of the insulinemia response closely mimics what is observed in the clinical setting, as the parameters quantifying tissue insulin sensitivity, liver glucose output, and pancreatic secretory capacity are varied to reflect Normal Glucose Tolerance, Impaired Fasting Glycemia, Impaired Glucose Tolerance, IFG+IGT and finally Type 2 Diabetes Mellitus.