While hundreds of thousands of controllers are represented in the model, the behaviour of the whole system is determined by specifying only few controller population metaparameters: these are the characteristics of the distributions from which each controller’s parameters are randomly sampled (glycemia firing threshold; rapidity of return to normal excitability determining the length of the refractory period; rate of increase of insulin packet size upon persisting hyperglycemia, etc.). The gene discussed is INS; the disease is Hyperglycemia.