We also performed an in-depth characterization of FLNC transcript and protein levels in FTD patients with different genetic etiologies and found that elevated FLNC levels observed in the frontal cortex of FTLD-TDP patients are mainly associated with the GRN p.0(IVS1 + 5G > C) loss-of-function mutation. The gene discussed is FLNC; the disease is frontotemporal dementia.