For 5 FLNC variant carriers with FTD, another genetic causal or risk variant had previously been identified (Table 2), 2 with a C9orf72 repeat expansion, 2 with a GRN loss-of-function mutation and 1 with the TREM2 p.R47H risk allele (Table 2). Here, TREM2 is linked to frontotemporal dementia.