Further in line with the human data is that Flnc levels remained unchanged in two mouse models of AD, including Tg2576 mice overexpressing the Swedish APP variant p.KM670/671NL (Taconic Farms Inc.)or T8B7 mice expressing the PSEN1 p.G384A mutation (Additional file 2: Figure S2b) [50]. The gene discussed is PSEN1; the disease is Alzheimer disease.