RYR2 and heart disorder: To investigate whether calcium signaling had a role in the observed alterations of myocardial structure, we followed the expression of a selected panel of calcium regulated genes and proteins involved in cardiac function and homeostasis known to change expression levels and/or phosphorylation status in heart disease, including Rcan1, Pln, Ryr2, Slc8a2, Slc8a3, Slc8a4, Atp2a1, and Atp2a2 [48].