HAND2 and congenital heart disease: Hand2 has been identified as a key contributor to congenital heart disease [45] and was 2- to 2.5-fold decreased in expression in high- and low-dose TCDD-exposed female hearts, miR-155, recently associated with hypertrophic cardiomyopathy in humans [46], was decreased about 3-fold in high-dose TCDD-exposed female hearts.