DPP4 and type 1 diabetes mellitus: No differences were observed in the insulitis score at 4 weeks of treatment because it still corresponds to a relatively earlier phase of the pre-diabetic state (10–12 weeks of age), whereas differences in insulitis observed at week 6 of treatment (12–14 weeks of age) may be precluding the final protective effect of DPPIV inhibitor in reducing the incidence of T1D.