IL12B and type 1 diabetes mellitus: In human type 1 diabetes (TIDM), the genetic susceptibility locus, IDDM18, is located near a regulatory allele of the IL-12 p40 gene (IL-12B) [42], and single nucleotide polymorphisms in this region associate with an earlier age of T1DM onset and accelerated deterioration in glycemic control [43, 44].