FGFR1 and breast carcinoma: An important mechanism of oncogenic FGFR1 activation is amplification of its gene locus at chromosome 8p11, which is found in 10–20% of squamous cell carcinomas of the lung [15–18], in about 10% of hormone receptor positive breast carcinoma [19–21], 10–17% head and neck squamous cell carcinomas [22] and 6% of small cell carcinomas of the lung [23].