While i) human autosomal form of Alport syndrome is shown to affect males and females equally [12], and ii) mice bearing Col4a4 splice site mutation, another model of Alport syndrome, show similar progression of albuminuria in males and females [5], relatively little is known about sex-specific susceptibility to disease progression in Col4a3KO mice. This evidence concerns the gene COL4A4 and Alport syndrome.