Other studies showed Pak1 up-regulation in cancer tissue over normal matched tissue of 2.96-fold in squamous cell lung carcinoma [25] (Fig 6F), 2.23-fold in lung adenocarcinoma [26] (Fig 6H), and of 2.16-fold in invasive breast carcinoma (TCGA invasive breast). Here, PAK1 is linked to squamous cell lung carcinoma.