As shown in Fig 1B, Pak1 RNAi infection of Rb-/- MC3T3 cells increased the intensity of beta-catenin labeling in intercellular spaces, suggesting a partial restoration of adherens junctions (top panel, arrow), compared to Rb-/- MC3T3 cells infected with scrambled control adenovirus (middle panel). The gene discussed is PAK1; the disease is infection.