Some of 5-HT1A receptor ligands are already used in the therapy of depression, e.g. vilazodone and vortioxetine (serotonin reuptake inhibitors and partial 5-HT1A agonists) or generalized anxiety disorder–buspirone (a partial 5-HT1A receptor agonist) [7,8]. Here, HTR1A is linked to depressive disorder.