In contrast, down regulation of annexin A4 (Anx4, Spot F327), annexin A8 (Anx8, Spot F139), moesin (MSN, Spot F169), keratin 7 (KRT7, Spot F21), keratin 8 (KRT8, Spot F78), gelsolin (GEL, Spot F70, F71) and tublin alpha 1c (TUBA1C) was detected in the IUGR fetuses. This evidence concerns the gene ANXA4 and fetal growth restriction.