The favorable effect of RDN on glucose metabolism is supported by investigations of 2 female patients with polycystic ovary syndrome (PCOS),14 a disease characterized by insulin resistance, obesity, diabetes, and blood pressure elevation related to sympathetic nervous activation.55 After both patients took RDN, fasting plasma glucose declined and insulin sensitivity improved by 17.5% in the presence of unaltered bodyweight at 3-month follow-up. Here, INS is linked to diabetes mellitus.