Nevertheless, the DREAMS-Study,15 investigating the effects of RDN on insulin sensitivity and blood pressure in patients with metabolic syndrome, contradicted the result of better glucose metabolism of those researches mentioned above.12–14 In that study, 29 patients fulfilling the criteria for metabolic syndrome were enrolled, of whom 5 (17%) were T2DM. The gene discussed is INS; the disease is type 2 diabetes mellitus.