MUC5AC and adenocarcinoma: Our research also described the typical feature of gastric signet-ring cell on CLE: the presence of large vacuolated cells rich in mucin with solitary peripheral nuclei (typical signet-ring cells).29 As above-mentioned, the current study implied a phenomenon and trend that CLE might has advantage than ME-NBI for the diagnosis of those early gastric UD-type adenocarcinoma with nonneoplastic foveolar epithelium mucosal surface.