NF, one of the major axonal cytoskeletal proteins, was related to the injury of either central, peripheral, or both nervous systems.25–29 Increased pNF-H levels were also observed in patients with an acute and chronic phases of neurological diseases such as multiple sclerosis, febrile seizures, hypoxic-ischemic encephalopathy, and other conditions.30–32 Consistent with those studies, the current study identified a significant increase in serum pNF-H levels in DPN patients after excluding central nervous system disorders and other diseases reported to cause elevated serum. The gene discussed is DNM2; the disease is central nervous system disorder.