Recent studies of MDA-MB-453, a cell line model of molecular apocrine breast cancer, revealed that the AR cistrome has a similar profile to the ERα cistrome in MCF7 breast cancer cells, thereby stimulating a luminal gene signature [12], and that AR promotes HER2 signaling by activating Wnt and c-MYC signaling pathways [13–15]. The gene discussed is ESR1; the disease is breast carcinoma.