Interestingly, comparison of genes regulated by forced over-expression of AR-V7 in MDA-MB-453 cells (this study) versus LNCaP prostate cancer cells [40] revealed a complete absence of overlapping targets (Supplementary Table S5), further supporting the concept of a unique AR-V7-driven transcriptome in ERα-negative breast cancer. Here, ESR1 is linked to Familial prostate cancer.