We further explored if rs1129406 (ATF1, 12q13), rs12303082 (FAM186A, 12q13), rs6580742 (FAM186A, 12q13), rs16888728 (UTP23, 8q24) and rs3184504 (SH2B3, 12q24) genotypes affect the CRC risk differentially by sex, age at diagnosis, tumor site, stage and MSI status (Supplementary Table 15). The gene discussed is FAM186A; the disease is neoplasm.