SH2B3 and glioblastoma: Though predicted to be located within a transcription factor binding site (POLR2A) in lymphoblastoid, leukaemia and glioblastoma cell lines, it seems unlikely affect binding according to RegulomeDB (score 3a)19 or influence expression of SH2B3 in lymphoblastoid cell lines20, 21 and other tissues22, 23.