We further explored if rs1129406 (ATF1, 12q13), rs12303082 (FAM186A, 12q13), rs6580742 (FAM186A, 12q13), rs16888728 (UTP23, 8q24) and rs3184504 (SH2B3, 12q24) genotypes affect the CRC risk differentially by sex, age at diagnosis, tumor site, stage and MSI status (Supplementary Table 15). This evidence concerns the gene ATF1 and neoplasm.