ACE and diabetes mellitus: When analyzed as a continuous variable, higher log-transformed Hcy was associated with higher incident CKD (Table 2), even after adjusting for age, gender, diabetes, SBP, body mass index (BMI), smoking, cholesterol, high density lipoprotein cholesterol (HDL-C), triglycerides, eGFR, and previous use of angiotensin converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs).