EZH2 and hepatocellular carcinoma: Indeed, other researchers have recently suggested the relevance of the rs3757441 EZH2 SNP in hepatocellular carcinoma: Yu et al. reported that patients who carried at least one C allele have a higher lymph-node-metastasis risk than did patients carrying the wild-type allele [16], thus confirming the potential functional relevance of this SNP in cancer cells.