This SNP genotype has been linked with worse prognosis among mCRC patients treated with chemotherapy with or without an anti-vascular endothelial growth factor antibody: our data confirm in primary tumors that the C allele is linked with increased EZH2 expression and activity, thus providing additional evidence for a functional relevance of this SNP in CRC biology. The gene discussed is VEGFA; the disease is colorectal carcinoma.