Although more is known about the role of NR2F2 in PCa [45, 49], both COUP-TF genes, NR2F1 and NR2F2 display nearly 100 % homology in their DNA-binding domain (DBD) and ligand- binding domain (LBD), though no natural ligand has been identified for these COUP-TFs [50]. This evidence concerns the gene NR2F1 and posterior cortical atrophy.