Unsupervised hierarchical clustering of copy number profiles of all luminal CHEK2*1100delC and BRCAX samples, i.e. including samples with high TILs, suggests a great degree of heterogeneity amongst the CHEK2*1100delC breast cancers comparable to that seen in the BRCAX breast cancers (Fig. 2). Here, CHEK2 is linked to breast cancer.