Celastrol’s induction of miR-223 helps to explain the mechanisms behind some of celastrol’s other known actions, such as celastrol’s newly identified potential in anti-obesity applications, since miR-223 is not only a major regulator of cholesterol (miR-223 can reduce cholesterol) [35], but also an insulin sensitivity enhancer [36]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.