The ability of Ivermectin to induce an inflammatory and potentially immunogenic form of cell death is supported by 1) its ability to stimulate autophagy; and 2) recent data showing that ATP release from cancer cells undergoing ICD is mediated by the Ivermectin-sensitive P2X4/P2X7-gated Pannexin-1 channels16. Here, P2RX4 is linked to cancer.