Moreover, while Ivermectin does not significantly impact surface CRT (S6A,B, Fig. 6C, bottom panel), its ability to up-regulate plasma membrane exposure of mannose-6-phosphate (M6P) receptors could potentially render cancer cells susceptible to bystander CTL/NK cell-mediated killing, as described recently (Fig. 6C, top panel)36, 37. Here, CALR is linked to cancer.