APOE and Cognitive impairment: The striking congruency between these later-life cognitive deficits, and our early-life APOE-ε4-influenced PCC modulations, supports the idea that poorer cognitive health in older age may reflect a—potentially predictable—sequence of functionally selective neural changes experienced across the lifespan; individual susceptibility to these brain changes is most likely influenced by key lifestyle and genetic factors, including APOE-ε4 status17.