PROM1 and renal cell carcinoma: H&E staining of tumors generated in SCID mice by RCC-41-PDX-2, and RCC-41-PDX-2/CD133−, RCC-41-PDX-2/CD133+ and their respective clones, shows that PDX-2 xenografts exhibit histopathology similar to that observed in PDX-1 tumors, consisting of highly mitotic undifferentiated carcinomas, and rare clear cells (Figure 7A).