Thus, we propose that serial xenografts of PDX-1/CD132+ in SCID mice progressively produce differentiated tumors, as shown by the increased expression of E-cadherin, the absence of vimentin expression, and the massive appearance of CD133−/EPCAM+ cells, that in PDX-1/CD132+-1.2 xenografts constituted more than 70% of the non-CSC tumor cell bulk. The gene discussed is PROM1; the disease is neoplasm.