Given the a priori evidence of MMPs associated with spontaneous ICH susceptibility, this study evaluated whether the genetic variations of promoters in MMP-2 rs2285053 (-735 C>T), TIMP-2 rs7503607 (-269 C>A), and TIMP-2 rs7503726 (-261 G>A) would predispose to SDICH, affect hemorrhage size, and modify the 30-day outcome in the Taiwan population. This evidence concerns the gene MMP2 and hemorrhage.