Notably, the adoptive transfer of in vitro generated Th17 cells into mice is also sufficient to drive ELF development in a model of multiple sclerosis.19 The expression of the cell surface glycoprotein podoplanin (also called gp38) by Th17 cells was required for the development of these lymphoid follicles in the central nervous system. This evidence concerns the gene PDPN and multiple sclerosis.