APOE and atherosclerosis: Although lymphoid neogenesis is typically associated with exacerbation of chronic inflammatory processes, a recent study demonstrates a protective role for ELFs in atherosclerosis.107 ELFs develop in the aorta of aged Apoe−/− mice where they correlate with disease severity.123 These structures were typically located adjacent to atherosclerotic plaques where they control immune cell trafficking, antigen presentation and T‐cell priming and differentiation.107 Hence, aortic ELFs may play an important role in establishing local T‐cell immunity during ageing in atherosclerosis.