NFE2L2 and fibrosarcoma: The newly transcribed Nrf2 undergoes nuclear translocation and binds to small musculoaponeurotic fibrosarcoma (sMaf) transcription factors, including MafF, MafG and MafK [14], driving the transcription of Nrf2-responsive genes containing DNA antioxidant responsive elements (AREs) in their promoter [13] (Figure 1).