In studies on P. falciparum: Fletcher and Avery [48] showed that 12 Malaria Box compounds are potential inhibitors of the Coenzyme A pathway; Hain et al. [49] identified a target (Atg8-Atg3 protein-protein interaction) for six Malaria Box compounds in the parasite’s blood and liver stages; Lucantoni et al. [50] found 64 gametocidal compounds amongst the Malaria Box compounds; and Paiardini et al. [51] found two compounds active against neutral aminopeptidases M1 and M17. This evidence concerns the gene ATG3 and malaria.