Recently, it is found out that Bcl-2 is the therapeutic target of miR-17-92 cluster in BCR-ABL positive Acute Lymphoblastic Leukemia (ALL) [53] and overexpression of miR-221/222 downregulate Bcl-2 and induce apoptosis in gastrointestinal stromal tumors [54]. This evidence concerns the gene ABL1 and gastrointestinal stromal tumor.