PCNT and microcephaly: The second pedigree mutation (IVS26-15A→G, R1334SfsX5, n = 2) in northern Pakistani microcephaly pedigrees [15, 17], on the other hand, results in a truncated 1338 amino acid protein that lacks the EB1 binding region, the C-terminal SMC and the p35- and pericentrin-binding motifs.