Moreover, recent data revealed that both type I (IFNα/β) and type II (IFNγ) IFN signatures are upregulated in both peripheral blood and minor salivary gland tissues derived from SS patients while the IFNγ/IFNα mRNA ratio in diagnostic salivary gland biopsies could predict the in situ lymphoma development in the setting of SS [72, 73]. Here, IFNG is linked to lymphoma.