An interesting finding from a large study (GWAS) in Han-Chinese [46] but not in European population revealed that a polymorphism in the GTF2I gene (namely, rs117026326) (encodes a transcription factor involved in both T-cell signaling [99] and activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation [100]) is strongly associated with SS development with overall risk (OR) scores higher than other SS-associated identified genes including MHC-II genes, STAT4, and TNFAIP3 [46]. The gene discussed is STAT4; the disease is synovial sarcoma.