Specific haplotypes of the BAFF gene could discriminate SS patients with lymphoma from SS patients without lymphoma and healthy controls [62] and a functional mutation His159Tyr of the BAFF receptor (BAFF-R), previously found to confer an increased risk in patients with NHL through activation of the alternative NF-κB pathway [118], has been found to be more prevalent in SS population compared to healthy controls. Here, NFKB1 is linked to lymphoma.