The expression data from PC Cl3 cells, PC PTC1 cells transformed with the papillary thyroid cancer PTC oncogene, and PC E1A cells immortalized with the aggressive adenovirus E1A oncogene (Figures 2(d)–2(f)) treated with the p38 inhibitor indicated similar upregulation of sod3 expression, suggesting oncogene-dependent silencing of sod3 via p38 MAPK activation. The gene discussed is RET; the disease is thyroid gland papillary carcinoma.