Inhibition of the kinase had a minor impact on the SOD3 gene expression in human Nthy cells (Figure 2(a)), whereas SOD3 expression was significantly increased in human TPC1 papillary thyroid cancer cells and in human 8505c anaplastic thyroid cancer cells (Figures 2(b) and 2(c)). Here, SOD3 is linked to thyroid gland undifferentiated (anaplastic) carcinoma.