SOD3 and thyroid gland papillary carcinoma: To validate the cell models for the aims of the current study, we investigated the expression of SOD3 mRNA. SOD3 expression was gradually downregulated in papillary thyroid cancer TPC1 cells and anaplastic thyroid cancer 8505c cells compared to control Nthy cells modeling normal thyroid cells (Figure 1(a)), suggesting a correlation between the mRNA expression and the degree of differentiation of the cancer [7, 30].