GNRH1 and central precocious puberty: Similar to the findings of the current study, in a study by Carel et al., prepubertal responses were observed in the GnRH tests in the 3rd month of treatment in 85% of patients, who were diagnosed with CPP and treated with a leuprolide dose of 3.75 mg administered once every 28 days, and the authors concluded that a low-dose treatment was effective in the majority of patients [6].