BTG3 and systemic lupus erythematosus: Such a lack of specificity of anti-dsDNA antibodies for renal flare was also observed in other conventional parameters such as anti-nucleosome antibody (ANA), levels of complements C3 and C4, proteinuria, and urine sediment [30], which led to searching other reliable immunological markers for identifying those SLE patients with active nephritis [16].