NFKB1 and pyelonephritis: While the NF-κB status of the urothelium can have a clear impact on the pathogenesis of acute cystitis, it remains to be seen whether it influences the disease course and clinical presentation of other forms of microbe-related conditions of the urinary system, including asymptomatic bacteriuria (ABU)60, recurrent urinary tract infections and pyelonephritis.