Several infection-induced SUMO targets also are involved in mRNA maturation events, such as 3′ end pre-mRNA processing (CPSF1, CPSF2, FIP1L1, RBBP6, and WDR33), splicing (CLASRP, SFPQ, and ZRANB2), and nuclear RNA quality control (ZC3H18, ZCCHC7, and PAPD5). The gene discussed is ZC3H18; the disease is infection.