The fact that RASSF1A cooperates with APC loss to promote intestinal tumors [49] suggests that SRC activation may contribute to colorectal tumorigenesis by promoting the tyrosine phosphorylations of both β-catenin and YAP1 that are required for nuclear localization and transcriptional activation [16, 29, 39]. The gene discussed is RASSF1; the disease is intestinal neoplasm.