In addition to SRC-mediated destruction of cell-cell contacts in epithelial cells, we find that mesenchymal MDA-MB-231 cells also appear to require YES-mediated phosphorylation of YAP for nuclear targeting, as has been implicated previously for RUNX2 complexes [39] and in cancer-associated fibroblasts (CAFs) in response to mechanical stress [50]. This evidence concerns the gene YAP1 and cancer.