LGMN and Alzheimer disease: To confirm the role of AEP-mediated APP cleavage in the pathogenesis of AD, we injected WT mice with adeno-associated virus (AAVs) encoding human mutant APPSLA expressing the Swedish, London and Austrian mutations that are associated with early-onset familial AD40or an AEP-uncleavable form APPSLA/N373A/N585A.