ANXA2 and hepatocellular carcinoma: The result confirmed that the expression levels of ONECUT2, IGF2BP1, and ANXA2 were significantly elevated in non-tumor tissues compared to normal tissues (P = 0.0116, P = 0.0380 and P = 0.0145, respectively), and further elevated in HCC tissues (P = 0.0270, P = 0.0003 and P < 0.0001, respectively) (Figure 4A).