DNA microarray demonstrated that BMP7 treatment upregulated a cluster of genes associated with metastasis suppressor (RASAL2, DLC1), EMT/migration/invasion arrest (DLC1, ZNF395), tumor suppressor/cell cycle control (CDC14B, TGFBR1, AKAP10, RASEF, ARIH2), cell differentiation and transcription activation (ATXN1, ZNF638, BRPF3, MLL, IGF1R, IL6ST), insulin signaling/glucose uptake/premature senescence (PIK3C2A, IGF1R), and anti-inflammation/immune response (POU2F1, IRAK1BP1). Here, INS is linked to neoplasm.