In particular, we found primary glioblastoma tumor cells express CD105 (endoglin), which is an MSC surface marker and a component of the TGF-β receptor complex that binds to TGF-β1 and TGF-β3, and modulates TGF-β signaling [48], thus suggesting a direct link between TGF-β-induced EMT and the gain of stem cell properties in glioblastoma and GSC. This evidence concerns the gene ENG and neoplasm.