AGO2 and nasopharyngeal carcinoma: Therefore, one mechanism by which this could occur is if the risky rs3928672 A allele can influence binding of transcription factor in the intron 4 of AGO2. Further studies are needed to clarify which polymorphism(s) may possess functional consequence(s) for AGO2, and in turn to provide mechanistic plausibility for the observed association between rs3928672 and involvement of lymph node metastasis of NPC.