For example, miR-370 reduces leukaemogenesis in acute lymphoblatic leukaemia (ALL) and CML by targeting the oncogene FoxM1 [16, 17], whereas miR-451 is known to targets TSC1 and GRSF1 in CML [18], and miR-196b targets HOXA in paediatric acute ALL [19]. This evidence concerns the gene TSC1 and chronic myelogenous leukemia, BCR-ABL1 positive.