PVT1 and acute promyelocytic leukemia: In addition to a gain in 8q24, the well-known MYC protein is a transcriptional activator of PVT1 [32] and increased in human APL [31], and it has been reported that treating APL cells with ATRA inhibits the expression of c-myc mRNA [39], suggesting that elevated PVT1 expression may also result from MYC protein activation in APL cells.