Although there are a few reports demonstrating that PVT1 plays an important role in the pathogenesis of several cancers, it is not yet clear whether PVT1 is involved in the regulation of APL, which is a unique subtype of acute myeloid leukemia (AML) that results from a blockade in granulocyte differentiation during the promyelocytic stage. This evidence concerns the gene PVT1 and acute myeloid leukemia.