SOST and neoplasm: In conclusion, consistent with previously published preclinical experiments that support the inhibition of Wnt signaling as a potential mechanism for hindering tumor cell growth, tumor survival, and metastasis, in the current study we show that sclerostin, a Wnt antagonist, has the potential to inhibit prostate cancer invasion, in vitro, and to reduce the incidence of macroscopic metastases and osteolysis in NSG mice, in vivo.