FOXC2 and lymphedema: Genetic etiology of SEDAC has been suggested.[5, 6] We previously investigated 2 familial SEDAC pedigrees associated with lymphedema-distichiasis syndrome (LDS) (OMIM 153400) and identified heterozygous loss of function mutations in FOXC2 (forkhead box C2).[6] In the study, we also investigated seven sporadic SEDAC patients, but found no FOXC2 mutation.