The N-acetyl-galactosaminyl-transferases (GalNAc-Ts or GalNTs) are responsible for synthesizing the Thomsen-nouvelle antigen (Tn), one of cancer-associated O-glycans [11, 12], whose expression is positively associated with many types of cancer and correlates with metastasis and even poor survival [13–16]. Here, B4GALNT1 is linked to cancer.