On the other hand, during the bladder development of mouse, KLF5 is essential for the formation and terminal differentiation of urothelium [11], and a recently systematic study of human bladder cancer tissues uncovered that KLF5 was mutated in up to 8% of MIBC, suggesting the importance of this gene in bladder cancer [12]. The gene discussed is KLF5; the disease is urinary bladder cancer.