Published data shows that KLF5 is genomically deleted or down-regulated in several types of cancers (i.e., prostate, lung and leukemia) but overexpressed in other types (i.e., breast, esophagus, stomach and colorectal) [6], and these contradictory profiles of KLF5 may be due to its cellular and context-dependent regulation of target gene transcription [8]. The gene discussed is KLF5; the disease is leukemia.