As shown above, growth factors (EGF and bFGF) and stimuli (PMA and LPA) that activated downstream oncogenic signaling (such as PKC, MEK/Erk and PI3K/Akt) could elevate the expression of KLF5, then increased VEGFA transcriptional efficiency and promoted bladder cancer angiogenesis. This evidence concerns the gene PRRT2 and urinary bladder cancer.