It has been reported that exogenous KLF5 expression increased cell cycle transition and up-regulated cyclin D1 in TSU-Pr1 bladder cancer cells [9], and accelerated degradation of KLF5 protein performed by curcumin impaired tumor growth of bladder cancer cells in vitro and in vivo [10]. The gene discussed is KLF5; the disease is urinary bladder carcinoma.