Moreover, several tumor suppressors (CDKN2A/B, CDKN1B, CDKN2C, ARID1A, KIF1B, SMARCB1, PTEN, DMD, LATS2 and SMAD4) and oncogenes (CCND2, KRAS, BRAF, ETV1, EGFR, MYCN, SMO and TERT) were found recurrently altered in metastatic GIST specimens and rarely in localized tumors. This evidence concerns the gene LATS2 and neoplasm.