We observed a dramatic increase in the expression of several proinflammatory markers such as Il17a, Ifnγ, Tnfα, IL-1β and Ifitm1, and chemokines such as Ccl1, Cxcl10, Ccl22 and Xcl1, in ATMINΔLNBS1ΔL mice displaying splenomegaly, compared to the other genotypes (Fig 4B). This evidence concerns the gene IFNG and Splenomegaly.