TNF and Splenomegaly: We observed a dramatic increase in the expression of several proinflammatory markers such as Il17a, Ifnγ, Tnfα, IL-1β and Ifitm1, and chemokines such as Ccl1, Cxcl10, Ccl22 and Xcl1, in ATMINΔLNBS1ΔL mice displaying splenomegaly, compared to the other genotypes (Fig 4B).